Skip to Content
Home > Wellness > Health Library > Immunosuppressive Medicines for Lupus
Depending on the drug, an immunosuppressive medicine may
be given in pill form, weekly injections, or by
intravenous (IV) pulse therapy (injection given
lupus erythematosus, or SLE) is an
autoimmune disease, in which the
immune system attacks the body's own tissues as though
they were foreign substances. Immunosuppressive medicines reduce
inflammation and suppress the immune system.
Azathioprine, cyclophosphamide, and
mycophenolate mofetil are used to
kidney disease associated with lupus.
Methotrexate is used to
control skin rash and joint pain caused by lupus. It may be tried to allow less corticosteroid medicine to be used.1
Methotrexate may help control skin rashes
and joint pain.2 There also are reported benefits for controlling more severe
lupus symptoms, such as inflammatory conditions of the kidneys and tissues
around the heart and lungs. But there has been little research in these
Other immunosuppressive medicines are used for more severe lupus. Most studies have been done using one of the immunosuppressives, along with corticosteroids, for lupus that is causing serious kidney problems (lupus nephritis). But they are also used to try to control other serious symptoms of lupus, such as inflammation around the heart and lungs. Azathioprine, cyclophosphamide, and mycophenolate mofetil are the most commonly used medicines. They can take several weeks to reach full effectiveness, but they generally help decrease serious symptoms. As the immunosuppressive takes effect, the amount of corticosteroids can usually be reduced.2
Side effects of immunomodulator medicines include:
Rare side effects include:
Extremely rare side effects of azathioprine include a possible increased risk of cancer. Mycophenolate mofetil may increase the risk of cancer of the lymph system (lymphoma) and other types of cancer.
Drug Reference for a full list of side effects. (Drug Reference is not
available in all systems.)
Combinations of immunosuppressants and corticosteroids can be very effective but can also increase
the risk of side effects. So regular follow-up and monitoring by your doctor is essential.
Some people may take medicines such as nonsteroidal anti-inflammatory drugs (NSAIDs) or antimalarial drugs while they are taking immunosuppressive medicines. Your doctor will work with you to find the best medicine or combination of medicines for you.
Immunosuppressants can cause birth defects. Do not
take immunosuppressants if you are pregnant or wish to become pregnant. If you are a man who is taking this medicine, do not try to conceive a child.
cytotoxic medicines have been associated with a small increase in the risk for certain cancers. But if you have severe, possibly life-threatening
lupus, you may decide that a medicine's risk is outweighed by its potential
Complete the new medication information form (PDF)new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
Tassiulas IO, Boumpas DT (2009). Clinical features and treatment of systemic lupus erythematosus. In GS Firestein et al., eds., Kelley's Textbook of Rheumatology, 8th ed., vol. 2, pp. 1263–1300. Philadelphia: Saunders Elsevier.
Hahn BH (2012). Systemic lupus erythematosus. In DL Longo et al., eds., Harrison's Principles of Internal Medicine, 18th ed., vol. 2, pp. 2724–2735. New York: McGraw-Hill Medical.
May 10, 2012
Anne C. Poinier, MD - Internal Medicine & Nancy Ann Shadick, MD, MPH - Internal Medicine, Rheumatology
How this information was developed to help you make better health decisions.
To learn more visit Healthwise.org
© 1995-2014 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
Our interactive Decision Points guide you through making key health decisions by combining medical information with your personal information.
You'll find Decision Points to help you answer questions about:
Get started learning more about your health!
Our Interactive Tools can help you make smart decisions for a healthier life. You'll find personal calculators and tools for health and fitness, lifestyle checkups, and pregnancy.
Feeling under the weather?
Use our interactive symptom checker to evaluate your symptoms and determine appropriate action or treatment.