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CADASIL

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report CADASIL is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • cerebral autoDom arteriopathy w/subcortical infarcts & leukoencephalopathy
  • hereditary multi-infarct dementia

Disorder Subdivisions

  • None

General Discussion

CADASIL is a rare genetic disorder affecting the small blood vessels in the brain.
The age of onset, severity, specific symptoms and disease progression varies greatly from one person to another, even among members of the same family. CADASIL is an acronym that stands for:

(C)erebral - relating to the brain (A)utosomal (D)ominant - a form of inheritance in which one copy of an abnormal gene is necessary for the development of a disorder.

(A)rteriopathy - disease of the arteries (blood vessels that carry blood away from the heart)

(S)ubcortical - relating to specific areas of the brain supplied by deep small arteries

(I)nfarcts - tissue loss in the brain caused by lack of oxygen to the brain, which occurs when blood flow in the small arteries is severly reduced or interupted

(L)eukoencephalopathy - refers to lesions in the brain white mattter caused by the disease and well observed on MRI

Resources

United Leukodystrophy Foundation
224 N. 2nd St.
Suite 2
DeKalb, IL 60115
Tel: (815)748-3211
Tel: (800)728-5483
Email: office@ulf.org
Internet: http://www.ulf.org/

NIH/National Institute of Neurological Disorders and Stroke
P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
TDD: (301)468-5981
Internet: http://www.ninds.nih.gov/

CADASIL-Together We Have Hope
3605 Monument Drive
Round Rock, TX 78681
USA
Tel: (512)255-0209
Fax: (512)255-0209
Tel: (877)519-4673
Email: info@cadasilfoundation.org
Internet: http://www.cadasilfoundation.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  2/7/2013
Copyright  2009, 2013 National Organization for Rare Disorders, Inc.

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